Diversity in Overall Activity Regulation of Ribonucleotide Reductase
نویسندگان
چکیده
منابع مشابه
Inhibition of ribonucleotide reductase activity by IC202C.
suppresses DNAsynthesis by inhibition of ribonucleotide reductase.4) Ribonucleotide reductase plays an essential role in DNAsynthesis in most organisms.5) The enzyme is a nonheme iron-containing protein, which requires ATPand Mg2+ as co factors. As previously reported that IC202C has art affinity against Fe(III) ion,3) we have examined the effect of IC202C on ribonucleotide reductase activity u...
متن کاملNew ribonucleotide reductase inhibitors with antineoplastic activity.
possible cancer chemotherapeutic agents. Howeven, pre himinary data indicate that these compounds are toxic and are not effective in humans (4, 14). In order to develop an effective chemothemapeutic agent for which the mode of action is inhibition of nibonucleotide meductase activity, a number of ahiphatic and aromatic hydroxamic acids and their corresponding amides and esters were synthesized ...
متن کاملImportance of the Maintenance Pathway in the Regulation of the Activity of Escherichia coli Ribonucleotide Reductase†
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides in all organisms. The Escherichia coli class Ia RNR is composed of alpha and beta subunits that form an alpha 2beta 2 active complex. beta contains the diferric tyrosyl radical (Y (*)) cofactor that is essential for the reduction process that occurs on alpha. [Y (*)] in vitro is proportional to RNR activ...
متن کاملRibonucleotide reductase regulation in response to genotoxic stress in Arabidopsis.
Ribonucleotide reductase (RNR) is an essential enzyme that provides dNTPs for DNA replication and repair. Arabidopsis (Arabidopsis thaliana) encodes three AtRNR2-like catalytic subunit genes (AtTSO2, AtRNR2A, and AtRNR2B). However, it is currently unclear what role, if any, each gene contributes to the DNA damage response, and in particular how each gene is transcriptionally regulated in respon...
متن کاملRibonucleotide reductase activity in ether-treated cells of Agmenellum quadruplicatum.
Ribonucleotide (cytidine 5'-diphosphate) reductase activity can be detected in situ in cells of the blue-green alga Agmenellum quadruplicatum, strain PR-6, after the cells are made permeable by treatment with ether. The Agmenellum reductase resembles the enzyme from Escherichia coli.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2015
ISSN: 0021-9258
DOI: 10.1074/jbc.m115.649624